As promised, here is a look at the second new ingredient (actual a family of ingredients) you will see in the upcoming TEST FACTOR™ from Molecular Nutrition, and many other sports nutrition products in the months to come.

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ActeoFIT™ is a family of herbal extracts standardized for the natural high-affinity Selective Estrogen Receptor Modulator (SERM) ligand acteoside. SERMs are a class of compounds that act on the estrogen receptor, blocking its action in certain tissues (antagonist). As such, they may counter some of the undesirable effects of estrogen such as increased water and fat retention, and male gynecomastia. SERMs are not purely anti-estrogenic, however, and may also exert “estrogen-like” action in other tissues (agonist). As such, they represent a balance of pro- and anti-estrogenic activity. This dual action is important because estrogen in certain tissues is necessary for bone strength, immune system function, cardiovascular protection, cholesterol management, and libido (sexual desire).

There are dozens of studies supporting the use of acteoside and its source herbs in the field of sports nutrition. For example, one series of preliminary experiments with rats have demonstrated an increase in endurance during exercise, along with inhibited creatine kinase and improved glycogen stores.  This means better performance, along with preserved muscle mass and energy (glycogen is the primary source of fuel during exercise).  Further still, hyperplasia and hypertrophy of muscle cell mitochondria were observed without damage to the myofibril.  This means muscle fiber growth (size and number), without the same level of damage as normally expected (anti-catabolic).

Other studies with ActeoFIT’s key active ingredient have demonstrated improved memory and learning ability. SOD activity, a potent antioxidant in the body, was also significantly increased in serum and brain, and the malondialdehyde of liver and serum was notably decreased. These properties alone make the herb of especially strong interest for potential “anti-aging” and general health use. Clinical trials are presently underway on one of the acteoside-containing herbs to see if it can stimulate neuronal differentiation of adult neural stem cells in the brain, as well as improve long-term neurodegenerative conditions. Additional studies suggest it may support improved cholesterol and blood pressure management, and increase Nerve Growth Factor levels for a “neurotrophic” effect.